YMS Series – Neoantigen Vaccine Research

On Wednesday, April 16, at 17:30 GMT+2 we will hear a talk about #Neoantigen #Vaccine:

Dr. Anja Mösch, "NeoAgDT: optimization of personal neoantigen vaccine composition by digital twin simulation of a cancer cell population", Biomedical AI, NEC Laboratories Europe GmbH, Germany

Keywords: neoantigen, cancer, immunology, digital twin, simulation

Abstract: Neoantigen vaccines make use of tumor-specific mutations to enable the patient’s immune system to recognize and eliminate cancer. Selecting vaccine elements, however, is a complex task which needs to take into account not only the underlying antigen presentation pathway but also tumor heterogeneity. We developed NeoAgDT, a two-step approach consisting of: (i) simulating individual cancer cells to create a digital twin of the patient’s tumor cell population and (ii) optimizing the vaccine composition by integer linear programming based on this digital twin. NeoAgDT shows improved selection of experimentally validated neoantigens over ranking-based approaches in a study of seven patients.

Resources:

• Paper: https://academic.oup.com/bioinformatics/article/40/5/btae205/7645414

Format: Online, free to attend, no registration is required: Zoom

Organization: YMS is organized by RSBI and is linked to RoBioinfo Seminars

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